Friday, October 24, 2014

Cells' Powerhouses Were Once Energy Parasites: study upends current theories of how mitochondria began

Source: University of Virginia
Date Published: October 16, 2014
Link: http://www.sciencedaily.com/releases/2014/10/141016165955.htm

Summary:
This article provides an alternative theory to the current theories. U.Va. biologist Martin Wu suggested that the current theories -- all claiming that the relationship between the bacteria and the host cell at the very beginning of the symbiosis was mutually beneficial -- are likely wrong. Instead, he believed that the relationship likely was antagonistic -- that the bacteria were parasitic and only later became beneficial to the host cell by switching the direction of the ATP transport. He reconstructed the gene content of mitochondrial ancestors, he predicted it to be a parasite that actually stole energy in the form of ATP from its host. He also identified many human genes that are derived from mitochondria may contribute to several diseases, including Alzheimer's disease. This study has the potential to change the way we think about how mitochondria began.

Relevance:
This article is related to what we are learning these days because mitochondria is a part of a cell. Mitochondria is important to us because it provides energy to our cells. But the study in this article uncovered the real identity of the ancestor of the mitochondria. This article also talks about the symbiosis relationship, which we learned in unit 1. It stated in the article that the idea of the relationship between the bacteria and the host cell at the very beginning was mutualism was wrong. Instead, it is parasitism.

4 comments:

  1. Did the article mention why switching the direction of the ATP transport was good for the host cell? How and why did the bacteria change the direction?

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    1. The article didn't mention why switching the direction of the ATP transport was good for the host cell, but I believe it's because by switching the direction, as we learned today, it provides energy to the cell. The article stated that a billion years ago, mitochondria was a bacteria that stole energy from the ATP. But it evolved overtime and became a organelle that actually provides energy to the cell. That's why it is good for the host cell. For the next one, it is a great question but I honestly don't know the answer for that question. Maybe it's related to evolution because it changed the direction over a long period of time.

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  2. The article states that the theory that "the relationship between the bacteria and the host cell at the very beginning of the symbiosis was mutually beneficial" is completely wrong. What differences would having parasitic bacteria as opposed to having a beneficial bacteria from the start make to the evolution of cells? How did cells evolve to produce their own mitochondria if it was originally an invasive bacteria?

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    1. Those are great questions, but I can't understand the first one. Sorry! And for the second question, the answer is -- a cell can actually evolve with a parasitic bacteria and there is a possibility that the parasitic bacteria become beneficial as it evolved with the host cell. It's called host-parasitic co-evolution. It is a special case of co-evolution. Here's a link for you: http://en.wikipedia.org/wiki/Host%E2%80%93parasite_coevolution
      You can scroll down to check out the references on that page because it's wikipedia.

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