Sunday, January 11, 2015

Natural Selection is Furthering Mutations That are Making Skin Paler


Source: (Science Daily), University of the Basque Country
Link: http://www.sciencedaily.com/releases/2014/12/141205100058.htm
Date: January 9, 2015

Summary:

     Human skin color varies according to the latitude and, therefore, according to the intensity of ultraviolet light. Individuals living at low latitudes generally have darker skin, whereas those living at high latitudes have paler skin. It has been determined that evolution is furthering mutations that are lightening the skin, probably owing to the need to synthesize vitamin D at latitudes where there is reduced solar irradiation. However, in turn, this increases the probability of developing melanoma or other types of skin cancer. Natural selection furthers certain mutations so that individuals can have paler skin, since at certain latitudes having a skin with a dark pigmentation prevents the synthesis of adequate levels of vitamin D, essential for survival. Vitamin D can be obtained through the diet, but also in an indirect way as UV light passes through the skin. Dark skin contains the pigment melanin, which acts as a barrier and prevents UV rays from penetrating. At high latitudes where the intensity of UV light is very low, this is a problem, as insufficient quantities of vitamin D are synthesized.

     Why does natural selection further a mutation that causes cancer? Vitamin D is essential for skeletal mineralization and development, and the lack of this vitamin can lead to various problems in children's health. Yet the skin cancer melanoma is a cancer that tends to appear in adult life, following the reproductive phase. Theoretically, as these adult individuals have by now produced offspring, they are no longer important in evolution. 

Relevance: 
     
     This topic relates to what we are learning about evolution in Chapter 14. This article relates to natural selection, the process whereby organisms better adapted to their environment tend to survive and produce more offspring, which we have talked about in class. Darwin's theory of "Descent with Modification" presented in Chapter 14 states that over time and generations, traits providing reproductive advantage become more common within a population. This directly relates to my article, in which over time, human skin depigmentation has occurred due to the need to synthesize vitamin D. This has occurred due to the process of natural selection, in which individuals who carry the trait for paler skin have a higher chance of surviving and passing on this trait to their offspring at higher latitudes, where there is less solar irradiation. 

4 comments:

  1. This is very interesting. But what other factor affects the skin color, other than the latitude and the ultraviolet light?

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    1. The skin color of humans is affected by many substances, but mainly the pigment melanin, produced by cells called melanocytes. The differences in skin color result from differences in the amount of melanin that melanocytes produce.
      In the past, humans living in areas near the equator, where there is much direct sunlight, would gradually have increasingly darker skin through natural selection, as the melanin acts as a UV barrier and prevents certain skin cancers. The further away from the equator human lived, the lighter their skin tones would be, as lighter skin would be needed to synthesize vitamin D from sunlight. These traits are then passed onto their children, and so on and so forth.

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  2. What did you mean by "these adult individuals have by now produced offspring, they are no longer important in evolution?" Do you believe that natural selection will continue to play a role in this situation?

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    Replies
    1. Vitamin D-deficiency due to prevented synthesis from darker skin tones, is an issue because it has a large effect on children who require the vitamin D to grow. Often, children who suffer from this deficiency have a high mortality rate, and thus die before they are able to reproduce and pass on their genes for darker skin. However, Melanoma and other types of skin cancer mainly affect adults who have passed the reproductive phase, and thus have already passed on the genes for lighter skin color to their children. Therefore, natural selection no longer accounts for these people as the limiting factors brought on by melanoma and other skin cancers have no effect on reproduction.

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